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KMID : 0376219860230010209
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Chonnam Medical Journal
1986 Volume.23 No. 1 p.209 ~ p.216
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Effect of Amitriptyline on the Submaxillary Blood Flow in Cats
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Abstract
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It has been known that long-term treatment with the tricyclic antidepressants commonly produces side effects such as dry mouth, constipation, impotence, sweating, urinary retention and blurred vision.
Although all these side-effects have been explained by an atropine-like blockade of parasympathetic drive, detailed action mechanism of these drugs was not fully understood. Among these side-effects, dry mouth is produced by decreased salivation. Salivary secretion is closely related not only to cellular activity but to the blood flow of the glands as well. However, the effect of these drugs on the blood flow of the glands has not been investigated. The present study is undertaken to explore the effect of amitriptyline, a tricyclic antidepressant, on the submaxillary blood flow and its effect was compared with the action of atropine on the blood flow in ketamine-anesthetized cats.
1) The submaxillary blood flow was not affected by the administration of small dose of amitriptyline(0. 05-0.5mg/kg, i. v. ), but it was transiently decreased by larger dose of this drug(2mg/kg) and the submaxillary blood flow was not affected by any dose of atropine.
2) Increased submaxillary blood flow and the salivary secretion caused by stimulation of the chorda tympani were decreased together by large dose of of amitriptyline, and the decreased blood flow was immediately recovered but the inhibitory effect on the salivary secretion was persisted for considerable period of time. On the contrary, the increased blood flow by the nerve stimulation was not affected by any dose of atropine, whereas the salivary secretion was completely abolished.
3) The increased blood flow evoked by the administration of pilocarpine was blocked either by amitriptyline or by atropine.
4) Small dose of amitriptyline produced a decrease in systemic arterial blood pressure and tachycardia, while larger dose decreased both blood pressure and heart rate.
These results suggest that the transient decrease in the submaxillary blood flow by amitriptyline may not be direct action of this drug on the smooth muscle structures of the blood vessel and rather it may be the indirect action of this drug accompanying the cardiac dysfunction.
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KEYWORD
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